Definition: Osirification is a process in which a material, such as a bone or muscle, undergoes chemical changes to form a new structure. This process occurs through an enzyme called collagenase. The key step in this process is the cleavage of collagen fibers by the enzyme and the formation of a new collagen fiber. This process can be used for the treatment of various diseases and conditions such as osteoporosis, which results from bone loss due to decreased collagen production.