Definition: Leukodystrophy is a type of genetic disorder that affects the functioning and structure of blood cells. It results from defects in the development or function of one or more blood cell lines, such as platelets or red blood cells. These defects can cause abnormal numbers, shapes, or structures to appear on the surface of these cells, leading to various symptoms, including bleeding, infections, and organ damage. Leukodystrophies are caused by a variety of genetic mutations that occur in the