Definition: Leucoplakia is a condition characterized by a patchy, white or brownish appearance of the skin on the lips and tongue. It is often associated with a genetic disorder called Leukodystrophy. The specific cause of this condition remains unknown but it has been linked to mutations in genes involved in the production of melanin, which is responsible for the pigment that gives skin its color. The term "leucoplakial" was coined by Dr. Paul Ehrlich and