👉 The term "orthologue" is used to describe a genealogical relationship where two or more genes are the same function but in different domains. In other words, they have similar functions within their respective domains but differ in structure and function. For instance, consider the protein encoded by the gene "GATA1" which regulates the differentiation of cells into the myeloid lineage. This gene is orthologous to the gene "myeloid" in the same family (the GATA family