👉 The term "karyoschisis" is a medical condition that occurs when the chromosomes of one egg cell are not properly separated from those of another egg cell during fertilization. This can lead to abnormal development or even death if the resulting embryo is not viable for survival. Karyoschisis is often caused by genetic abnormalities, such as chromosomal rearrangements, mutations, or other structural changes in the chromosomes that prevent normal division and function in the developing embryo. The exact cause of