👉 Echinulation is a condition in which the membrane of an embryo's outer layer, called the endoderm, breaks. This can occur during development and is often associated with conditions such as neural tube defects or brain malformations. It happens when the endoderm begins to break down and release its contents into the surrounding tissue, leading to a loss of internal structure. In some cases, echinulation may cause permanent damage to the embryo's body, making it difficult for it to continue
