👉 Porphyria is a rare genetic disorder characterized by skin and mucosal ulcers, often in the mouth or around the lips. It can be caused by mutations in the porphyrin biosynthetic pathway, which leads to an accumulation of porphyrins in tissues. The specific cause of porphyria is not known, but it is thought to be related to a defect in the enzymes that break down porphyrins or the production of porphyrins themselves. This disorder