👉 In biology, a helicoprotein is a protein that has a conformational change in which a side chain moves from one amino acid to another. This type of conformational change is known as a hydrogen bond or an isoelectric point shift. Helicoproteins are found in the bilayer of the cell membrane and play important roles in regulating cell function, including signaling pathways and protein synthesis. For example, the helicoprotein from the bacterium Escherichia