👉 Human experimentation during the 20th century, exemplified by studies such as those conducted at the infamous Nazi medical trials and the Tuskegee Syphilis Study, involved unethical practices that sought to test the efficacy or dangers of treatments on unwilling or under-informed human subjects without obtaining their informed consent. These experiments led to significant ethical and legal reforms in research involving human participants, emphasizing the importance of autonomy, dignity and protection of human rights.