Definition: Spheromeres are a type of cell membrane in the endoplasmic reticulum (ER) of eukaryotic cells that play important roles in protein synthesis and transport. They are composed of two layers, one for ATPase activity and another for vesicle trafficking, and they are located at the periphery of the ER and are surrounded by a plasma membrane. Spheromeres have been found to be highly efficient at transporting proteins between their target molecules, allowing them to perform