Definition: Peri-ergy is a term used in medicine to describe the process by which the immune system attacks healthy tissue, such as skin, liver, and lungs. This is known as autoimmunity. It occurs when the body mistakenly attacks healthy tissue with antibodies that are produced by the immune system. The goal of treating perioralgic syndrome (peri-ergy) is to help the patient manage symptoms effectively while also improving their quality of life.