Definition: Demanganization is a process in which a DNA sequence is modified to make it more resistant to mutation during replication, thereby reducing the risk of errors. This technique can be used to improve the accuracy and reliability of genetic testing by preventing mutations from occurring during the replication process. The exact mechanism behind demanganization varies depending on the specific type of DNA modification being performed, but it typically involves altering the base pairing or the presence of specific nucleotides in the sequence.