Definition: Cholinolytic is a term used in medicine, specifically in the field of neuromodulation therapy. It refers to an enzyme called cholinesterase that breaks down acetylcholine, a neurotransmitter. This process helps regulate various bodily functions such as heart rate, muscle tone, and nerve impulse transmission. In neuromodulation, a cholinolytic is typically used in the context of electrical stimulation or neurostimulation techniques to treat conditions such as Parkinson's disease, Alzheimer