Definition: The antispasmodic word in Greek means "noxious substance," referring to a material that causes discomfort or pain. Definition: Antispasmodic is a medical term which means a substance, usually found in pain relievers like ibuprofen, that makes an object unpleasant and can cause distress. It is also used to refer to an external stimulus or force that causes the body to become uncomfortable (like touching a hot stove).