Definition: Antidiuretic refers to a medication that helps prevent or suppress the need for urination, often due to kidney dysfunction. It works by regulating urine production and preventing excessive urination. Detailed Definition: Antidiuretic drugs (ADRs) are medications designed to reduce the amount of water in the body, allowing for more time without needing to urinate. They typically work by reducing the levels of potassium, a mineral responsible for maintaining proper fluid balance, which can cause an increase in urine volume and potentially lead to bladder problems. For example, medication like pregabalin (ibuprofen) or metoclopramide (methysergic acidethylamide), used in combination with other treatments, can be effective at reducing the need for urination in people with chronic kidney disease.