Definition: Word: Ankylosing Spondylitis Definition: Ankylosing Spondylitis (AS) refers to an autoimmune disease that causes spondylosis in the spine, especially discs, joints, ligaments and tendons. The symptoms include: - Pain - Limited movement - Changes in joint fluid levels - Difficulty walking or standing The inflammation is often caused by a specific antibody against the Sod1 gene. It can cause changes in bone density and damage to connective tissues like cartilage and tendons, leading to pain, stiffness, and mobility issues. Symptoms may appear suddenly, with symptoms often first appearing after an initial injury. Symptom progression may be gradual or sudden. Treatment options include: - Medications (e.g. steroids) - Physical therapy - Injections - Immunotherapy (therapy that targets specific immune cells in the body)