Definition: Oral orrogenyx (noun) - "an enzyme involved in secretory function that regulates blood flow to the kidneys." Definition: A hormone released from certain glands in the body, primarily in response to stress and infection, which helps regulate kidney function by decreasing the production of urine. Detail definition: Oral orogeny is the secretion of a hormone, adrenocorticotropic hormone (ACTH), into the bloodstream that stimulates the kidneys to excrete more urine, leading to water loss. The secretion also activates the sympathetic nervous system, increasing heart rate and blood pressure, which in turn promotes fluid retention and swelling in the legs and ankles.