Definition: 45107: A synthetic drug used in cancer therapy, specifically for treating advanced and recurrent glioblastoma multiforme (GBM). N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)phenyl]propanamide is a derivative of 45107. The compound has been found to be an effective treatment for GBM by inhibiting tumor cell proliferation, angiogenesis, and motility. It works by blocking the ability of tumor cells to secrete various growth factors necessary for cancer progression. This compound was identified in a series of human glioma patients with advanced disease using multiple biopsies. N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)phenyl]propanamide is commonly marketed as the name of the drug, 45107, for GBM treatment.
45107. N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)phenyl]propanamide; 921631-42-7