👉 Unirritative is a term used in medicine and psychology to describe substances or activities that cause irritation, discomfort, or pain. It refers to substances such as alcohol, caffeine, nicotine, certain medications, and excessive amounts of exercise that can lead to feelings of irritability, agitation, or anxiety. Unirritative substances are often associated with stress, anxiety, and depression, and they can have a negative impact on overall well-being.