👉 Sickle cell anemia is a genetic disorder that affects the production of red blood cells in the bone marrow, leading to abnormal and irregular-shaped red cells. This condition can be further divided into two subtypes: sickle-cell anemia and microsickle cell anemia. In sickle cell anemia, the hemoglobin (red blood cell protein) is mutated, causing it to form a sickle shape in its structure, making it harder for oxygen to pass through and potentially leading to complications