👉 Macrocytic refers to a condition in which the red blood cells (RBCs) of an adult or child are too large, typically more than 3.5 mm in diameter. This is commonly associated with certain medical conditions such as sickle cell disease and iron deficiency anemia. In macrocytic hemoglobin is typically less than 16 g/dL (0.7 mg/dl). It can affect the oxygen-carrying capacity of the blood, leading to symptoms like