👉 Wash math, short for washout effect, refers to the temporary reduction in the apparent concentration of a drug or chemical in a biological system due to rapid elimination or removal from the body. This phenomenon occurs when the rate of excretion (e.g., through urine or feces) significantly exceeds the rate at which the substance is absorbed or maintained, leading to a lower-than-expected concentration in the bloodstream or tissue over time. This can complicate drug dosing and therapeutic efficacy, as the drug levels may drop below the minimum effective concentration before a new dose is administered. Understanding wash math is crucial in pharmacokinetics and drug development to ensure optimal dosing regimens and patient safety.
