👉 Tramadol's mechanism of action involves both opioid and serotonin-norepinephrine reuptake inhibition. It binds to mu-opioid receptors, mimicking the effects of endogenous opioids like endorphins, thereby reducing pain perception. Additionally, tramadol inhibits the reuptake of serotonin and norepinephrine, enhancing their availability in the synaptic cleft and contributing to its analgesic and mood-stabilizing effects. This dual action makes tramadol effective for managing moderate to severe pain while potentially alleviating milder symptoms of depression or anxiety.
