👉 The Tennessee infection, also known as Tennessee tick-borne rickettsial infection or Tick-borne Rickettsia parkeri infection, is a rare and serious bacterial disease caused by Rickettsia parkeri, a bacterium transmitted to humans through the bite of an infected American dog tick (Dermacentor variabilis) or a similar tick species. After the tick bites, the bacteria enter the bloodstream and can spread to various organs, leading to symptoms such as fever, headache, fatigue, and muscle aches within days to weeks. If left untreated, it can progress to more severe complications, including arthritis, neurological issues, and even death. Early diagnosis and treatment with antibiotics, typically doxycycline or amoxicillin, are crucial for a favorable outcome, but prompt medical attention is essential due to the potential for rapid progression and severity.