👉 Preferred infection, or superinfection, refers to a secondary infection that occurs during an existing infection, typically when a host is already colonized by one pathogen. This phenomenon often arises due to immune suppression, altered microenvironments, or competition for resources within the host. For example, in a person with a compromised immune system, such as those with HIV/AIDS, a secondary bacterial infection like pneumonia can occur even if the initial infection was viral (e.g., influenza). Preferred infection is significant because it can lead to more severe disease outcomes, increased morbidity, and higher mortality rates compared to uncomplicated infections. Understanding this dynamic is crucial for developing targeted treatments and preventive strategies, especially in vulnerable populations.