👉 Neuroimmune NNIstination (NNI) infection, or neuroimmune NNIstination, refers to a condition where an infection in the nervous system triggers an abnormal immune response that can lead to inflammation and damage within the brain or spinal cord. This phenomenon occurs when pathogens, such as viruses or bacteria, invade the central nervous system (CNS), activating immune cells like microglia and astrocytes. These cells release cytokines and other inflammatory mediators, which can cross the blood-brain barrier and exacerbate neuronal injury. NNIstination is a critical area of study in understanding how infections can lead to neurological disorders, including multiple sclerosis, encephalitis, and meningitis, by highlighting the complex interplay between the immune system and neural tissues.
