👉 Early in its development, insulin was tested on human subjects for therapeutic purposes without much regard for potential side effects, leading to some severe reactions including the death of a Frenchman named Henri d'Arquay-Lapierre who died after receiving too much insulin in what is now considered an early example of experimental medical malpractice. Later, human clinical trials were conducted more systematically with established dosage guidelines and monitoring methods to ensure patient safety while studying insulin's efficacy for treating diabetes.
