👉 The controller-infection relationship describes how the immune system, particularly the body's controllers—T cells and natural killer (NK) cells—plays a crucial role in managing and eliminating infections. Controllers are essential for maintaining immune homeostasis and preventing excessive inflammation by regulating immune responses. When an infection occurs, these controllers help to control the pathogen's spread by targeting infected cells and modulating the activity of other immune cells. However, if the immune system fails to effectively activate or sustain its controller functions, it can lead to uncontrolled inflammation and tissue damage, potentially exacerbating the infection or causing autoimmune reactions. Thus, a well-functioning controller system is vital for a balanced immune response that effectively combats infections without causing harm.
