👉 Cholesterol engineering refers to the scientific manipulation of cholesterol levels and its metabolic pathways within cells to achieve desired therapeutic outcomes. This field involves modifying the production, uptake, and breakdown of cholesterol through genetic engineering, pharmacological interventions, or dietary adjustments. By altering genes responsible for cholesterol synthesis, transport, or receptor activity (like LDL receptors), researchers can reduce elevated LDL cholesterol levels, a key risk factor for cardiovascular diseases. Techniques such as CRISPR-Cas9 gene editing allow precise modifications to enhance the efficiency of cholesterol clearance or inhibit its synthesis. Cholesterol engineering also explores the production of modified forms of cholesterol, like statins' analogs, which can more effectively lower cholesterol levels while minimizing side effects. This approach holds promise for personalized medicine, enabling tailored treatments based on an individual's genetic profile and specific lipid abnormalities.
