👉 The beginning fluid, often referred to as the prostaglandin endothelium-derived relaxant (PDE5 inhibitor), is a naturally occurring compound produced by the endothelium, the inner lining of blood vessels. This fluid plays a crucial role in regulating blood flow by relaxing and widening blood vessels, particularly in the context of sexual arousal. When released, PDE5 inhibits the enzyme phosphodiesterase type 5 (PDE5), which breaks down cyclic guanosine monophosphate (cGMP). By preventing this breakdown, PDE5 allows cGMP levels to remain elevated, leading to smooth muscle relaxation and vasodilation. This process enhances blood flow to the genital area, facilitating erections in males and increased vaginal lubrication and blood flow in females, thereby supporting sexual function.
