👉 The ASN (Acid-Sensitive Nuclease) fluid is a component of the saliva that plays a crucial role in protecting teeth from acid attacks. It contains a high concentration of the enzyme kallikrein-activated proteinase (KAP), which is activated by acidic stimuli, such as those produced by bacteria in dental plaque. When the pH drops due to acid exposure, KAP cleaves and inactivates other enzymes like matrix metalloproteinases (MMPs) and cathepsins, preventing them from breaking down tooth enamel. This protective mechanism helps maintain the integrity of dental tissues by neutralizing harmful acids and reducing enamel erosion, thus contributing to oral health.
