👉 PIMPLES, or Peripheral Inflammatory Mediators, are a group of molecules that play crucial roles in the body's immune response and inflammation. They are primarily found in the skin and are released during inflammatory processes, contributing to redness, swelling, and pain. These mediators include cytokines, chemokines, histamines, prostaglandins, and leukotrienes. They act by recruiting immune cells to the site of injury or infection, increasing blood flow and vascular permeability, and sensitizing nerve endings to pain. The complex interplay of PIMPLES orchestrates the body's defense mechanisms, but their excessive or prolonged release can lead to chronic inflammation and associated diseases.
