👉 Antibodies, specifically immunoglobulins, are proteins produced by the immune system to recognize and neutralize foreign substances like pathogens (bacteria, viruses) and toxins. However, under certain conditions, these antibodies can release small peptides or fragments known as fumes or fragments, particularly when they undergo conformational changes or enzymatic cleavage. These fumes, often referred to as "antibody fragments" or "fragmented immunoglobulin peptides," are typically derived from the light chains of antibodies (IgA, IgD, and IgE) or the constant regions of heavy chains (CH2 domains). While these fragments are generally non-toxic and can serve as markers for immune responses, they can sometimes trigger inflammatory reactions or contribute to autoimmune conditions if they mistakenly target self-antigens. The release of these fumes is a complex process influenced by factors such as pH, temperature, and the presence of specific enzymes, making them an important area of study in immunology and therapeutic development.