👉 Pellagra is a chronic condition caused by a deficiency in the enzyme pyruvate kinase, which is involved in the breakdown of carbohydrates. This deficiency results in a lack of energy production and can lead to symptoms such as fatigue, weakness, and skin discoloration. The term "pellagras" refers to this condition, which is characterized by the accumulation of fat cells on the skin, leading to dark spots or patches that appear irregularly. Pellagra affects individuals with a genetic