👉 A leiomyosarcoma is a type of cancer that occurs in muscle cells. It's similar to a tumor but it doesn't grow on skin or other tissues. Like most types of cancer, it can spread and cause pain or other symptoms if it gets to the bone. Leiomyosarcomas are more common in people who have a family history of the disease. They usually appear as a lump or a mass in the muscles that they're attached to, like a muscle fiber.