👉 Berger's disease is a rare genetic disorder that affects the nervous system, specifically affecting the brain and spinal cord. It primarily affects individuals who are born with an abnormal gene called BRCA1 or BRCA2, which codes for a protein that regulates cell cycle checkpoints and DNA repair in cells. This condition often results from mutations in these genes, leading to mutations in other genes such as p53, which plays a critical role in regulating the cell cycle and DNA repair processes.