👉 Thrombin is a protein that is produced by the liver in response to blood loss or injury. It plays a crucial role in the activation of platelets and other clotting factors, which are necessary for the formation of blood clots during bleeding episodes. Thrombin is composed of two domains: the α subdomain (also known as thrombin) and the β subdomain (also known as fibrinogen). The α domain contains a catalytic region that binds to its target substrate,