👉 Sulfamethazine is a medication used to relieve mild to moderate symptoms of colds, flu, and other respiratory infections. It works by blocking the action of histamine, which is the chemical messenger that triggers inflammation in the body's immune system. This can help reduce the severity of symptoms such as sore throat, runny nose, and coughing. Sulfamethazine is commonly used for treating colds, but it should not be used to treat other respiratory infections like the flu