👉 Somatomedin, also known as somatostatin, is a hormone secreted by the pituitary gland in the brain. It plays a crucial role in regulating appetite and energy expenditure, particularly during periods of fasting or starvation. In the body, somatostatin acts as a negative feedback mechanism to regulate hunger and satiety. When the levels of this hormone are elevated, it signals the hypothalamus (the "master" area of the brain) to increase appetite, leading