👉 A polynucleotide enzyme, or a polynucleotide deacetylase is a protein that catalyzes the removal of acetyl groups from nucleotides. This process is essential for the synthesis of DNA and RNA, as well as for the regulation of gene expression in cells. The enzyme is responsible for removing acetyl groups from the 3' carbon of each nucleotide in a given sequence, which can lead to changes in the structure and function of the genetic material.