👉 Nitrators are a class of drugs used to treat high blood pressure and heart failure. They work by blocking the action of a substance called nitric oxide, which is released during physical activity or when the body is stressed. This leads to an increase in blood flow to the heart and increases the production of natriuretic peptides, which are hormones that help reduce blood pressure. Nitrators can be taken as pills, capsules, patches, or nasal sprays.