👉 Macromandibular is a medical condition that refers to an abnormal development of the mandible, or jawbone. The mandible is the upper part of your face, and it has four small bones that make up the jaw. These bones are called molars, premolars, and canines. The macromandibular problem may be caused by a variety of factors, including genetics, obesity, poor diet, or certain medications. It affects not only the mandible but also the