👉 The term "kakogenic" refers to a substance that can cause severe gastrointestinal symptoms in individuals with certain conditions, such as Crohn's disease. This condition is characterized by an inflammation of the small intestine and leads to abdominal pain, diarrhea, nausea, vomiting, fatigue, and sometimes fever. The specific substances causing this condition include toxins produced by the immune system or from gut bacteria that are overactive due to a deficiency in certain nutrients.