👉 Histoplasmosis is a fungal infection that occurs primarily in people who are at risk of developing autoimmune diseases, such as lupus. It is characterized by inflammation and destruction of healthy tissue throughout the body, including the lungs, brain, and intestines. Histoplasmoses can also be transmitted through respiratory droplets or contaminated food and water. The term "histoplasma" comes from the Latin word for "spider," as it resembles a spider's web.