👉 Fisetin is a synthetic metabolite of folic acid (also known as folate) that has been developed for its ability to improve brain function and reduce cognitive decline in Alzheimer's disease. It was first synthesized in 1972 by Dr. J. M. H. van der Laan, who later named it after his wife, Fiset. The compound is a precursor of folic acid and is used as an analog of folate for several medical applications.