👉 In biology, an epistasis is a relationship between two or more genes that result in different phenotypes. This means that one gene can have an effect on another gene, leading to a change in phenotype (the way an organism behaves). Epistasis occurs when a single gene has multiple alleles at the same locus, and these alleles do not have the same functional consequences. For example, consider two genes A and B, which are linked by their regulatory element. If both genes are expressed at