👉 Diffusion is a biological process in which substances diffuse from an area of high concentration into areas with lower concentrations. This can occur through diffusion through a cell membrane, diffusion across the plasma membrane (through the cytoplasm), or diffusion within a cell itself. In simpler terms, it's like water flowing down a slope and then out of a hole you dig in the ground. The substance that flows is called the solute, and the area where it flows into is called the concentration gradient.