👉 Buller's disease is a rare genetic disorder characterized by an inability to produce enough red blood cells, leading to various symptoms and complications in children. It affects around 1 in every 20,000 live births worldwide. The condition is caused by the absence or reduced production of fetal hemoglobin (HbF), which is responsible for transporting oxygen throughout the body. This leads to anemia, a state characterized by low red blood cell count and other symptoms such as fatigue,