Definition: Actin electrically refers to a cellular process in which actins, an intermediate filament, bind to other proteins through their actin-actinin (A3) complex. It occurs in many types of cells but is particularly important for maintaining cell polarity, as it prevents the cell from slipping or sliding along the membrane. The actinoelectrically complex contains both A1 and A2 subunits. The A1 unit binds to a specific protein, called the N-terminus of the actin filament (A3). The A2 unit acts like an electrostatic force between A1 and A3, repelling them towards each other. Actin is composed of two identical subunits: alpha subunit (also known as myosin) and beta subunit. Together they form a single monomer that is the basis for cell motility and tension during muscle contraction. The actinoelectrically complex is essential for maintaining proper alignment between the N-terminus of the A3 protein and the two subunits of the myosin alpha subunit. Without this interaction, the A3/A1-A2 complex would not be able to bind to other proteins, leading to misalignment or deformation. The actinoelectrically complex is also important for regulating the movement of the myofilament during muscle contraction, which is crucial for muscle force generation and tension.

actinoelectrically