Definition: Acertannin (Acertannin) is a yellow or brown-colored oil extracted from the seeds of the Acertaceae plant (Acer mandshuricum). It has been used in pharmaceutical formulations as an antihistamine, anti-inflammatory, and antioxidant for centuries. Acertannin is highly effective in neutralizing reactive oxygen species (ROS), which play a crucial role in cell death and disease progression. It can reduce the production of ROS by inhibiting the enzyme cyclosporine A, a key antioxidant that helps protect cells from damage caused by ROS. Acer mandshuricum, also known as "the white tree" or "the golden apple," is known for its high content of this oil due to its rich antioxidants and other compounds. The seeds are rich in flavonoids, which act as powerful antioxidants. Acertannin has several potential uses in pharmaceuticals, but it's currently used primarily for its anti-inflammatory properties and antioxidant benefits. It can be used in formulations like topical ointments or creams, capsules, or tablets, depending on the intended use. In summary, Acertannin is a yellow or brown-colored oil extracted from the seeds of the Acer mandshuricum plant. It's an important agent for its ability to neutralize reactive oxygen species (ROS) and inhibit cyclosporine A in protecting cells against oxidative stress. Its anti-inflammatory properties make it useful for various medical applications, including topical ointments and capsules.
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